Gene

cyp11c1

ID

ZDB-GENE-070828-1

Name

cytochrome P450, family 11, subfamily C, polypeptide 1

Symbol

cyp11c1 Nomenclature History

Previous Names

cyp11b2
cyp11b (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Involved in cortisol metabolic process. Predicted to localize to mitochondrial inner membrane. Is expressed in brain and endocrine system.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

33 figures from 21 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cyp11c1 Human Ortholog

No data available

Associated With cyp11c1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital adrenal hyperplasia	cyp11c1^{ihb284/ihb284} (AB)	standard conditions	Zhang et al., 2020
congenital adrenal hyperplasia	cyp11c1^{ihb285/ihb285} (AB)	standard conditions	Zhang et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017972	Cytochrome P450, conserved site
Family	IPR001128	Cytochrome P450
Family	IPR002401	Cytochrome P450, E-class, group I
Family	IPR008849	Synaphin
Family	IPR050479	Cytochrome P450, families 11 and 27
Homologous_superfamily	IPR036396	Cytochrome P450 superfamily

Domain Details Per Protein

Protein	Length	Cytochrome P450	Cytochrome P450, conserved site	Cytochrome P450, E-class, group I	Cytochrome P450, families 11 and 27	Cytochrome P450 superfamily	Synaphin
UniProtKB:A0A8M9PD87 InterPro	700
UniProtKB:A1XRK1 InterPro	518
UniProtKB:A0A8M6YV96 InterPro	701

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cyp11c1-201 (1) Ensembl	Ensembl		2,489 nt	Select Tool ZFIN BLAST
mRNA	cyp11c1-202 (1) Ensembl	Ensembl		1,776 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations